C. elegans possesses both male and hermaphroditic sex forms and can reproduce either autosomally or bisexually. Hidrophilous nematodes preferentially select male sperm at fertilization and can produce upwards of 1400 offspring by mating with males. By tracking the reproduction of C. elegans, we can find that...
Bacteria have developed a subtle defense system to eliminate the foreign invasion genes of viruses and can quietly remove viral genes from their own genomes. This defense system of bacteria...
Globally, parasitic helminths afflict billions of people and die of resulting complications every year. Currently, no effective vaccines are available for human use against any of these parasitic worm...
Cockayne syndrome (CS) is a congenital syndrome characterized by growth and development, mental retardation, and premature aging. It is an autosomal recessive genetic disease that occurs in 2.5 cases ...
C.elegans is a saprophytic species that has been emerging as a standard model organism since the early 1960s. This species is useful in numerous fields, including developmental biology, neurobiology a...
Fluorescent proteins (FPs) such as green fluorescent protein (GFP), firstly isolated from the jellyfish Aequorea victoria, are popular tools in C. elegans. They are genetically encoded markers which a...
C.elegans are the classical model system for studying small RNAs, some of which in can transfer information across generations. Prof. Oded Rechavi-led team at Tel Aviv University has discovered three rules that control transgenerational inheritance via small RNA molecules in C.elegans, challenging our traditional concepts regarding the limits of inheritance and evolution.
Obesity is a complex disease associated with having an excess amount of body fat, which can cause complications such as metabolic syndrome, high blood pressure and diabetes. Our bodies contain two typ...
RNA-binding proteins play important roles in maintaining drug resistance of leukemia. In a recent research, team of Dr. Tannishtha Reya from University of California San Diego revealed that the double...
Sickle cell disease (SCD) is a group of inherited red blood cell disorders. The disease is caused by a genetic mutation that produces a defective form of hemoglobin, the protein in red blood cells tha...
Cancer has become one of the serious threats to human health, and its treatment has become the focus of global medical strategy. Cancer metastasis is an important reason for its high lethality. Genera...
The novel coronavirus pneumonia outbreaks in Wuhan, China in the end of 2019 presents high infectiousness and has caused thousands of deaths. Performing nucleic acid test of COVID-19 by RT-PCR is one ...
The finding suggest that aging is not simply the result of one specific gene or pathway acting on its own, but rather combinations of genes or pathways interacting with each other, which may explain why no single specific gene that extends longevity in humans has been found.
Mutations in the β-globin gene, the essential component of adult hemoglobin (HbA; α2β2), results in either a production of aberrant sickle hemoglobin leading to sickle cell disease or an insufficie...
The CRISPR/Cas9 gene editing system has been widely used in the basic biomedical research. However, the preclinical safety of the CRISPR/Cas9 system lacks a comprehensive assessment. Previous studies ...
In late October 2019, a Harvard University-led team have elaborated the molecular and neural mechanisms of pheromone-related learning behaviors in C. elegans. A pheromone is known as a secreted or exc...
Researchers in University of Pittsburgh demonstrated that C. elegans missing TCER-1 protein, a homolog of human TCERG1, fight off bacterial infections better than ones with intact gene. TCER-1 is foun...
Researches by a Princeton University-led team have observed that C. elegans can transmit complex learned avoidance behaviors from parent to progeny via eggs and sperm cells, giving the offspring an inherited mechanism for surviving dangerous conditions.
According to a study published in Nature, titled Genetic variation in glia–neuron signalling modulates ageing rate, the genetic variation of a newly discovered signaling pathway affects the aging rat...
Professor Gilula Chair of Scripps Research and senior research author Dr. Benjamin Cravatt declare a new proposal of life extension pathway by interfering/suppressing of specific enzyme-associated pat...
Nematodes are the most abundant animals on the blue planet, filling all trophic levels in the soil food web. Knowing where these tiny worms live matters because nematodes play a critical role in the c...
