TDP-1 and FUST-1: The Dynamic Duo in Exon Inclusion Inhibition and Fertility Control

Eukaryotic gene expression is a multistep process, and the interaction between different regulatory levels is crucial for coordinating gene expression. Transcription factors (TFs) and RNA-binding proteins (RBPs) are two major classes of proteins that...

The Astonishing Discovery of Glutaminase: The Unsung Hero Behind Sperm Function

Decreased sperm function is one of the major causes of male infertility. In humans, abnormalities in sperm motility, morphology, and quantity can all affect conception. However...

Unlocking Longevity: The Role of 3-Hydroxyanthranilic Acid (3HAA) in Aging

Aging is accompanied by systemic physiological changes, many of which increase vulnerability to chronic diseases such as neurodegeneration, cancer, and cardiovascular disorders...

The Neuropeptidergic Connectome of Caenorhabditis elegans: Unlocking the Secrets of Neural Communication

In the field of biology, Caenorhabditis elegans (C.elegans) has become a “star organism” for scientists studying neuroscience due to its simple yet exquisite nervous system. For a long time, scientists have been committed to...

Cracking the Genetic Code of Behavior: How Variants in C. elegans Shape Foraging

Understanding the genetic basis of behavior is one of biology’s great challenges. In Caenorhabditis elegans, a nematode with diverse feeding behaviors, the neuroendocrine ligand daf-7 plays a central role in...

The Sleep-Active Neuron: A Guardian of Survival Beyond Slumber

Sleep has been a fascinating topic in exploring the mysteries of human and animal behaviour. It is orchestrated by...

Unlocking Nature’s Digestive Signals: The Role of Bacterial Peptidoglycan in C. elegans Adaptation

Survival in nature often hinges on adaptability, particularly in food consumption. For nematodes like C. elegans, which feed on diverse bacteria, the ability to...

Disease-associated Mutations in CHIP: A Key Regulator of Mitophagy

A study in Neurobiology of Disease has shed light on the role of C-terminus of HSP70 interacting protein (CHIP) in the regulation of mitophagy, a process critical for maintaining cellular health by...

From Stress to Strength: How Early-Life Stressors Enhance Longevity and Resilience

Is stress always a bad thing? This question has intrigued scientists for years, and recent findings suggest the answer may be more nuanced. Researchers have discovered that...

Reproductive Regulation in Caenorhabditis elegans: A New perspective on Mitochondrial Stress Response

Protein homeostasis (proteostasis) is essential for maintaining cellular and organismal balance, and its disruption is a defining characteristic of aging. The mitochondrial unfolded protein response (UPRmt) is...