Precise Sequence Replacement
Combination of the CRISPR/Cas9 sequence deletion and sequence knock-in technology allows researchers to make one-for-one substitution of DNA sequence, such as the promoter substitution, coding sequence substitution, gene swap.
Researchers can use this technology to study the function of both genomic genes and exogenous genes.
Gene replacement is the consequence of the combination of sequence deletion and sequence insertion.
Figure 1 Schematic diagram of precise sequence replacement
|Price||Turnaround(weeks)||You need to provide||Deliverables|
|Starts from 1699 USD*||5-8|
*The price depends on the deletion & insertion sizes and difficulties.
**If the precise nucleotide change leads to embryonic lethal, larva arrested, or sterile phenotype in homozygotes, the precise heterozygote becomes the deliverables. If you want balanced heterozygotes, we could provide a Balancer Cross Service at a price of 400 USD.
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