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C.elegans Made in SunyBiotech Contribute to Researchers Publishing a Hundred High-Quality Papers

2022-05-20 15:19

Founded in 2016, SunyBiotech Co., Ltd is committed to providing high-quality and efficient C. elegans gene editing services to prestigious university laboratories worldwide. Since our inception, SunyBiotech has registered the gene alleles Syb and PHX on CGC and Wormbase.

Since May 2017, SunyBiotech has undertaken C. elegans gene editing services. Our clients are spreading across Asia, Europe, North America, South America, and Oceania (see Figure 1). At present, 95 of the top 100 world-renowned universities in the QS Rankings are SunyBiotech clients.


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Figure 1: Global distribution of SunyBiotech clients


Europe: Denmark, Finland, Czech Republic, Norway, Portugal, Poland, Greece, Hungary, Italy, Belgium, the Netherlands, Austria, Sweden, Switzerland, Spain, Germany, France, and the United Kingdom.

Asia: China, India, Singapore, Japan, South Korea, Israel, Qatar, Saudi Arabia and Turkey

North America: the United States, Canada, and Mexico

South America: Uruguay and Argentina

Oceania: Australia


Till May 1st, 2022, our clients have published nearly 100 papers (see appendix) using a total of 239 strains edited by SunyBiotech, which makes us quickly went from 0 to 100 in four short years (see Figure 2). Among the 100 papers, there are 55 with an impact factor of more than 5, and 25 have an impact factor of more than 10 (calculated according to the impact factor of the journal when the paper was published). It is worth mentioning that 5 of them were published in the top journals of "NCS", including 4 in Nature and 1 in Cell.


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Figure 2: Cumulative number of papers using C.elegans made in SunyBiotech


In the past four years, “SunyBiotech C.elegans” has frequently appeared in world-renowned academic journals.

In October 2017, on the first anniversary of our establishment, the strain edited by SunyBiotech was published for the first time. Lionel Pintard (PI) published a paper entitled “Channel Nucleoporins Recruit PLK-1 to Nuclear Pore Complexes to Direct Nuclear Envelope Breakdown in C. elegans” in the well-known academic journal Developmental Cell, in which the strain PHX207 npp-1(syb207)IV was used.

In June 2019, “SunyBiotech C.elegans” was firstly listed on the top journal. Oded Rechavi (PI) published a paper in Cell entitled “Neuronal Small RNAs Control Behavior Transgenerationally” using two of our strains PHX776 rde-4(ne299);saeg-2(syb776) / PHX777 rde-4(ne299);saeg-2(syb777). In October of the same year, PHX1028 cup-5(syb1028)III was used in the paper “A secreted microRNA disrupts autophagy in distinct tissues of Caenorhabditis elegans upon ageing” published in Nature Communications by Shen Yidong (PI) from Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, which is the first time that “SunyBiotech C.elegans” has been used and published by Chinese scientists.

In March 2020, “SunyBiotech C.elegans” first appeared on Nature. Jerome Goudeau team published a paper entitled “Addendum: A lysosomal switch triggers proteostasis renewal in the immortal C. elegans germ lineage” using our strain PHX798 gld-1(syb798). In August of the same year, Oliver Hobert (PI) published a paper in Nature entitled “Unique homeobox codes delineate all the neuron classes of C. elegans” using up to 14 strains of “SunyBiotech C.elegans”, which also sets a record for the number of strains edited by SunyBiotech in a single paper.

After several years of accumulation, SunyBiotech has become a well-known brand recognized by the academic field of C.elegans. The quantity and quality of papers published by clients using “SunyBiotech C.elegans” has increased year by year. In 2020, the number of publications showed an explosive growth, reaching 41 papers. The good momentum still continues in 2022. In the first 4 months, the number of publications has reached the number of that in the whole year of 2019.

We believe that in the future, “SunyBiotech C.elegans” will provide a good experiment model for more researchers, reveal more scientific secrets hidden in C. elegans, and make greater contributions to the cause of life science.

We also sincerely thank every valued client of SunyBiotech. It is with your trust, support and dedication that so many high-level and high-quality academic papers have come out, and also inspire us to provide more refined and better services for every researcher who is committed to scientific research. We will continue to forge ahead towards the mission of “serve life science, benefit human beings”.

If you would like to get more information or services about SunyBiotech, please log on to our official website (https://www.sunybiotech.com/) or contact us at service@sunybiotech.com.


Appendix: Papers using “SunyBiotech C.elegans

Paper Title

Journal Name

Channel Nucleoporins Recruit PLK-1 to Nuclear Pore Complexes to Direct Nuclear Envelope Breakdown in C. elegans

Developmental Cell

Membrane Fluidity Is Regulated Cell Nonautonomously by Caenorhabditis elegans PAQR-2 and Its Mammalian Homolog AdipoR2

Genetics

Function and regulation of the Caenorhabditis elegans Rab32 family member GLO-1 in lysosome-related organelle biogenesis

PLOS Genetics

Chromatin Modifiers SET-25 and SET-32 Are Required for Establishment but Not Long-Term Maintenance of Transgenerational Epigenetic Inheritance

Cell Reports

BUB-1 promotes amphitelic chromosome biorientation via multiple activities at the kinetochore

eLife

Neuronal Small RNAs Control Behavior Transgenerationally

Cell

A secreted microRNA disrupts autophagy in distinct tissues of Caenorhabditis elegans upon ageing

Nature Communications

A fln-2 mutation affects lethal pathology and lifespan in C. elegans

Nature Communications

PCMD-1 Organizes Centrosome Matrix Assembly in C. elegans

Current Biology

Redox-dependent and redox-independent functions of Caenorhabditis elegans thioredoxin

Redox Biology

A developmental gene regulatory network for C elegans anchor cell invasion

Development

Heme peroxidase HPX-2 protects Caenorhabditis elegans from pathogens

PLOS Genetics

An autism-causing calcium channel variant functions with selective autophagy to alter axon targeting and behavior

PLOS Genetics

Sumoylation regulates protein dynamics during meiotic chromosome segregation in C. elegans oocytes

Journal of Cell Sicence

Single-strand annealing mediates the conservative repair of double-strand DNA breaks in homologous recombination-defective germ cells of Caenorhabditis elegans

DNA Repair

ALG-2/AGO-Dependent mir-35 Family Regulates DNADamage-Induced Apoptosis Through MPK-1/ERK MAPK Signaling Downstream of the Core Apoptotic Machinery in Caenorhabditis elegans

Genetics

ASNA-1 oxidation induced by cisplatin exposure enhances its cytotoxicity by selectively perturbing tail anchored protein targeting

bioRxiv

Microtubule Assembly and Pole Coalescence: Early Steps in C. elegans Oocyte Meiosis I Spindle Assembly

Biologist

Split-wrmScarlet and split-sfGFP: tools for faster, easier fluorescent labeling of endogenous proteins in Caenorhabditis elegans

BioRxiv

PCMD-1 bridges the centrioles and the PCM scaffold in C. elegans

biorxiv

Paper Title

Journal Name

The evolutionarily conserved ESRE stress response network is activated by ROS and mitochondrial damage

BMC Biology

Analysis of m6A RNA methylation in Caenorhabditiselegans

Cell Discovery

Epidermal Growth Factor Signaling Promotes Sleep through a Combined Series and Parallel Neural Circuit

Current Biology

Temporal, Spatial, Sexual and Environmental Regulation of the Master Regulator of Sexual Differentiation in C. elegans

Current Biology

Innate Immunity Promotes Sleep through Epidermal Antimicrobial Peptides

Current Biology

Establishment and maintenance of motor neuron identity via temporal modularity in terminal selector function

eLife

A conserved cysteinebased redox mechanism sustains TFEB/HLH30 activity under persistent stress

EMBO Journal

SLC17A6/7/8 Vesicular Glutamate Transporter Homologs in Nematodes

Genetics

A Region of UNC-89 (Obscurin) Lying between Two Protein Kinase Domains Is a Highly Elastic Spring Required for Proper Sarcomere Organization

Journal of Molecular Biology

Unique homeobox codes delineate all the neuron classes of C. elegans

Nature

Epidermal control of axonal attachment via β-spectrin and the GTPase-activating protein TBC-10 prevents axonal degeneration

Nature Communications

Cysteine synthases CYSL-1 and CYSL-2 mediate C. elegans heritable adaptation to P. vranovensis infection of cysteine synthases in progeny

Nature Communications

MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity

Nature Communications

The Rho-GEF PIX-1 directs assembly or stability of lateral attachment structures between muscle cells

Nature Communications

A wake-active locomotion circuit depolarizes a sleep-active neuron to switch on sleep

PLOS Biology

Roles for the RNA polymerase III regulator MAFR-1 in regulating sperm quality in Caenorhabditis elegans

Scientific Reports

The TRPV Channel OSM-9 is Required for Sleep-Dependent Olfactory Memory and is Expressed in Sensory Neurons That Do Not Promote Butanone Attraction

bioRxiv

A caveolin binding motif in Na/K-ATPase is required for stem cell differentiation and organogenesis in mammals and C. elegans

Science Advances

Modulating the endoplasmic reticulum stress response   attenuates neurodegeneration in a Caenorhabditis elegans model of spinal muscular atrophy

Dis Model Mech

The Caenorhabditis elegans CUB-like-domain containing protein RBT-1 functions as a receptor for Bacillus thuringiensis Cry6Aa toxin

PLOS PATHOGENS

Paper Title

Journal Name

Addendum: A lysosomal switch triggers proteostasis renewal in the immortal C. elegans germ lineage

Nature

An ABCG Transporter Functions in Rab Localization and Lysosome-Related Organelle Biogenesis in Caenorhabditis elegans

Genetics

Regulation of sleep by KIN-29 is not developmental

microPublication Biology

ceh-84, an unusual homeobox gene

microPublication Biology

Inhibition of the oligosaccharyl transferase in Caenorhabditis elegans that compromises ER proteostasis suppresses p38-dependent protection against pathogenic bacteria

PLOS Genetics

Ancestral function of Inhibitors-of-kappaB regulates Caenorhabditis elegans development

Scientific Reports

Alleviating chronic ER stress by p38-Ire1-Xbp1 pathway and insulin-associated autophagy in C. elegans neurons

PLOS Genetics

A Natural Mutational Event Uncovers a Life History Trade-Off via Hormonal Pleiotropy

Current Biology

Leveraging a gain-of-function allele of  Caenorhabditis elegans paqr-1 to elucidate membrane homeostasis by PAQR proteins

PLOS Biology

The Caenorhabditis elegans homolog of human copper chaperone Atox1, CUC-1, aids in distal tip cell migration

BioMetals

Host Mucin Is Exploited by Pseudomonas aeruginosa To Provide Monosaccharides Required for a Successful Infection

mBio

Alternative splicing of coq-2 controls the levels of rhodoquinone in animals

eLife

Alternative splicing of COQ-2 determines the choice between ubiquinone and rhodoquinone biosynthesis in helminths

BioRxiv

An omics analysis of genetic sleep loss in C. elegans

eDiss

A Mitochondrial Stress-Specific Form of HSF1 Protects against Age-Related Proteostasis Collapse

Developmental Cell

Tissue-specific isoforms of the single C. elegans Ryanodine receptor gene unc-68 control specific functions

PLOS Biology

Temporal transitions in post-mitotic neurons  throughout the C. elegans nervous system

BioRxiv

Characterization of two Caenorhabditis elegans Orthologs of Selenium-binding protein 1, associated with aging

dbt

Split-wrmScarlet and split-sfGFP: tools for faster, easier fluorescent labeling of endogenous proteins in Caenorhabditis elegans

Genetics

A nervous system-specific subnuclear organelle in Caenorhabditis elegans

Genetics

Paper Title

Journal Name

Telomeric double-strand DNA-binding proteins DTN-1 and DTN-2 ensure germline immortality in Caenorhabditis elegans

eLife

Cortical recruitment of centralspindlin and RhoA effectors during meiosis I of Caenorhabditiselegans primary spermatocytes

Journal of Cell Sicence

Interactions between the WEE-1.3 kinase and the PAM-1 aminopeptidase in oocyte maturation and the early C. elegans embryo

G3-Genes Genomes Genetics

The decrease of intraflagellar transport impairs sensory perception and metabolism in ageing

Nature Communications

A collection of toolkit strains reveals distinct localization and dynamics of membrane-associated transcripts in epithelia

Cell Reports

Rewiring of the ubiquitinated proteome determines ageing in C. elegans

Nature

Gene bookmarking by the heat shock transcription factor programs the insulin-like signaling pathway

Molecular Cell

A C. elegans model of C9orf72-associated ALS/FTD uncovers a conserved role for eIF2D in RAN translation

Nature Communications

PDZD-8 and TEX-2 regulate endosomal PI(4,5)P2 homeostasis via lipid transport to promote embryogenesis in C. elegans

Nature Communications

Identification of Novel Therapeutic Targets for Polyglutamine Diseases That Target Mitochondrial Fragmentation

MDPI

MON-2, a Golgi protein, mediates autophagy-dependent longevity in Caenorhabditis elegans

Science Advances

The LRR-TM protein PAN-1 interacts with MYRF to promote its nuclear translocation in synaptic remodeling

eLife

Alternative somatic and germline gene-regulatory strategies during starvation-induced developmental arrest

bioRxiv

Spliceosomal component PRP-40 is a central regulator of microexon splicing

Cell Reports

Combinatorial Assembly of Modular Glucosides via Carboxylesterases Regulates C. elegans Starvation Survival

Journal of the American Chemical Society

INPP5K and Atlastin-1 maintain the nonuniform distribution of ER–plasma membrane contacts in neurons

Life Science Alliance

Temporal transitions in the post-mitotic nervous system of Caenorhabditis elegans

Nature

Neuropeptide signalling shapes feeding and reproductive behaviours in male C. elegans

BioRxiv

Signaling via the FLP-14/FRPR-19 neuropeptide   pathway sustains nociceptive response to repeated noxious stimuli in C. elegans

Plos Genetics

TIMELESS-TIPIN and UBXN-3 promote replisome disassembly during DNA replication termination in Caenorhabditis elegans

EMBO Journal

Paper Title

Journal Name

Sphingosine 1-Phosphate Mediates Adiponectin Receptor Signaling Essential For Lipid Homeostasis and Embryogenesis

bioRxiv

The anterior Hox gene ceh-13 and elt-1/GATA activate the posterior Hox genes nob-1 and php-3 to specify posterior lineages in the C. elegans embryo

BioRxiv

Neuronal SKN-1B modulates nutritional signalling pathways and mitochondrial networks to control satiety

Plos Genetics

Overactivation of a sleep-active neuron decouples survival from the need to sleep

bioRxiv

An Optogenetic Arrhythmia Model—Insertion of Several Catecholaminergic Polymorphic Ventricular Tachycardia Mutations Into Caenorhabditis elegans UNC-68 Disturbs Calstabin-Mediated Stabilization of the Ryanodine Receptor Homolog

Frontiers   in Physiology

Loss of circRNAs from the crh-1 gene extends the mean lifespan in Caenorhabditis elegans

Aging Cell

Neuron-epidermal attachment protects hyper_x005f fragile axons from mechanical strain

Cell Reports

Robust regulatory architecture of pan-neuronal gene expression

Current Biology

SEMO-1, a novel methanethiol oxidase in Caenorhabditis elegans, is a pro-aging factor conferring selective stress resistance

BioFactors

Robust regulatory architecture of pan-neuronal gene expression

Current Biology

Neuron-epidermal attachment protects hyper_x005f fragile axons from mechanical strain

Cell Reports

Allosteric regulation of C. elegans AMP-activated protein kinase

microPublication Biology

Characterization of N- and C-terminal endogenously tagged Tyrosyl-DNA phosphodiesterase 2 (TDPT-1) C. elegans strains

microPublication Biology

Genetic analysis of daf-18/PTEN missense mutants for starvation resistance and developmental regulation during Caenorhabditis elegans L1 arrest

G3-Genes Genomes Genetics

A novel de novo FEM1C variant as a potential cause of neurodevelopmental disorder with absent speech, pyramidal signs, and limb ataxia

bioRxiv

The anterior Hox gene ceh-13 and elt-1/GATA activate the posterior Hox genes nob-1 and php-3 to specify posterior lineages in the C. elegans embryo

PLOS Genetics

Cortical microtubule pulling forces contribute to the union of the parental genomes in the Caenorhabditis elegans zygote

eLife

Sensory neuron transcriptomes reveal complex neuron-specific function and regulation of mec-2/Stomatin splicing

Oxford Academic

Sleep neuron depolarization promotes protective gene expression changes and FOXO activation

Current Biology

C. elegans Sine oculis/SIX-type homeobox genes act as homeotic switches to define neuronal subtype identities

bioRxiv