Reactivation of γ-globin expression through Cas9 or base editor to treat β-hemoglobinopathies

Mutations in the β-globin gene, the essential component of adult hemoglobin (HbA; α2β2), results in either a production of aberrant sickle hemoglobin leading to sickle cell disease or an insufficie...

The CRISPR/Cas9 gene editing system has been widely used in the basic biomedical research. However, the preclinical safety of the CRISPR/Cas9 system lacks a comprehensive assessment. Previous studies have shown that the CRISPR/Cas9 system causes a large n

The CRISPR/Cas9 gene editing system has been widely used in the basic biomedical research. However, the preclinical safety of the CRISPR/Cas9 system lacks a comprehensive assessment. Previous studies ...

The key of curing AIDS and the controversy of genomic edit

In 1996, Hongkui Deng Ph.D of NYU discovered CCR5, which lately becomes one of the keys of curing AIDS. Scientists found that in people with innate mutation of CCR5-∆32, HIV-1 is not able to bind wit...

Multiple sensory neurons modify the gustatory preference in C. elegans

Animals show behavioral plasticity through learning. Integrated multiple sensory inputs play a key role in generating proper behavioral output. In C. elegans, behavioral responses to NaCl is plastic a...

Developmental ROS individualizes organismal stress resistance and lifespan

Recently, research by Daphne Bazopoulou and Ursula Jakob of the University of Michigan found that a transient increase in reactive oxygen species (ROS), which occurs naturally during early development...

A large number of oncogenes are not on the chromosome

A research team led by Professor Paul Mischel from the Ludwig Cancer Institute at the University of California, San Diego found that a large number of oncogenes are not on the chromosome, but will fal...

Noxious heat has several effects on Caenorhabditis elegans behavior.

The nematode C. elegans turns into a protective sleep-like state while experiencing environmental stress or a short period of swimming. Team of Cheryl Van Buskirk from California State University reve...

High population density suppresses learning of harmful food

In late October 2019, a Harvard University-led team have elaborated the molecular and neural mechanisms of pheromone-related learning behaviors in C. elegans. A pheromone is known as a secreted or exc...

New CRISPR gene editing tool released

Many human genomic loci are associated with genetic diseases. Nowadays, it is possible to directly modify the genome to treat genetic diseases. Genetic editing has been achieved on animal models for t...

China approves Alzheimer's drug

On November 2, 2019, the State Drug Administration approved the application for the marketing of a new drug for the treatment of Alzheimer's disease--Nine Phase One® (Manlut sodium, code: GV-971)...